Co-location is a revitalization strategy that links the redevelopment of brownfields with nearby or adjacent properties that—like brownfields—can be a challenge to redevelop. Whereas brownfields redevelopment can occur on a site-by-site basis, a co-location approach considers how other challenging-to-redevelop properties, such as Superfund sites or vacant properties, can be revitalized in tandem with brownfields efforts. This report features examples of local governments that, in coordination with community and federal government partners, have undertaken co-location redevelopment. Project profiles from Denver and Indianapolis exemplify the benefits that co-location can yield, as well as indicate some strategies, best practices, and lessons learned that other local governments can adopt.