Disruptive market, demographic, fiscal, and environmental dynamics are fundamentally reshaping America’s economic landscape. In this new reality, the United States should think of infrastructure not in the general but in the specific, understanding the ways in which different infrastructure sectors—such as transportation, energy, and water—are governed, financed, and delivered. At the same time, metropolitan areas need to outline their priorities given their distinct economies, competitive advantages, and infrastructure needs. As public dollars become scarcer, we expect that the next generation of American infrastructure will require the public, private, and civic sectors to engage and partner in new ways. This white paper details the critical role infrastructure plays in the American economy, outlines the disruptive trends that are redefining the marketplace, and lays out a new path forward.